Defibrase® / Batroxobin

Defibrase® a thrombin-like enzyme purified from the snake venom of Bothrops moojeni. Defibrase is a pure single-chain glycopeptide with a molecular weight of approximately 36,000 daltons. In contrast to thrombin, which converts fibrinogen into fibrin by splitting off fibrinopeptides A and B, Defibrase only splits off fibrinopeptide A. The enzyme has a defibrinogenating effect and is used clinically for the treatment of thrombotic diseases.

PHARMACOLOGICAL ACTIVITY:
• Decreases fibrinogen levels, anticoagulation, inhibition of thrombogenesis
• Reduces whole blood and plasma viscosity
• Improves hemorheology and microcirculation

COMMON USE IN FINAL APPLICATIONS*:
• Acute cerebral infarction
• Ischemia caused by vascular occlusive diseases (e.g., thromboangiitis obliterans, deep vein thrombosis, pulmonary embolism, etc.)
• Peripheral and microcirculatory dysfunctions (e.g., sudden deafness, vibration disease)

*Please check available studies for further information