Aprotinin Concentrated Solution

Main therapeutic applications: • Use in cardiac surgery: Aprotinin is indicated for prophylactic use to reduce blood loss and blood transfusion in adult patients who are at high risk of major bleeding. In a finished dosage form, Aprotinin is used to reduce perioperative blood loss and transfusion requirements in patients during and following cardiopulmonary bypass (CPB) in the course of coronary artery bypass graft surgery. The effects of Aprotinin use in CPB involves a reduction in inflammatory response, through its inhibition of multiple mediators, which translates into a decreased need for allogeneic blood transfusions, reduced bleeding, and decreased mediastinal reexploration for bleeding. • Use in Fibrin sealant: Aprotinin is added to fibrin glue to delay the fibrinolytic action of plasmin and to stabilize the fibrinogen and thrombin components. • Use in biopharmaceutical processes: Aprotinin can be used for the isolation of proteins as well as for biopharmaceutical