PENTAPHARM's biotechnological R&D and manufacturing services for fermentation and downstream processing include:

  • Process optimization, increase of productivity for recombinant expression of proteins, using microbial expression systems, such as Escherichia coli and yeasts i.e. Saccharomyces cerevisiae and Pichia pastoris
  • Fermentation up to the 500 litres
  • Purification of inclusion-bodies from E.coli expression systems
  • Optimization of protein folding and scale-up
  • Biotransformation for customized molecules, including process optimization and manufacturing
  • Large-scale purification