Haemocoagulase

Product description:

Haemocoagulase is an isolated and purified snake venom enzyme from Bothrops atrox. It is free of any toxic protein substances. Haemocoagulase contains two different enzymes acting on blood coagulation; one has a thrombin like effect, the other has a thromboplastin like activity. In vitro, Haemocoagulase causes coagulation of fibrinogen by gradually splitting off fibrinopeptide A, giving rise to des-A-fibrin monomers, which polymerise end-to-end to fibrin. In the presence of platelet factor 3 Haemocoagulase activates factor X. In vivo, therapeutic doses of Haemocoagulase will not initiate intravasal coagulation. The des-A-fibrin monomer produced by Haemocoagulase remains in solution because it forms a complex with native fibrinogen. Haemocoagulase accordingly promotes and accelerates the physiological processes of haemostasis. Haemocoagulase shortens the bleeding and coagulation time. Following intravenous administration, the haemostatic effect becomes apparent after 5 to 10 minutes and lasts for 24 hours. After intramuscular or subcutaneous administration, onset of action occurs after 20 to 30 minutes and continues for 48 to 60 hours.

Main therapeutic applications:

Haemocoagulase is indicated in all fields of medicine, i.e. gynaecology, urology, gastro-enterology, dentistry for the prevention and treatment of haemorrhages of various origins, including cases where surgical treatment is required.